Hi Catherine, I was using natural progesterone cream for 7 months with good results – tho I still had some symptoms (tho minor) of imbalance. I decided to do a saliva test of my hormone levels, and foolishly decided to stop the progesterone supplementation for 6 weeks prior to doing the test – thinking I would then know what I “truly” was producing on my own. I have been sick since stopping the progesterone. The saliva test came back indicating normal levels of estrogen but deficient levels of progesterone. progesterone = 20 pg/ml (luteal), estradiol = 2.7 pg/ml (luteal): a ratio of P/E2 = 7 When I stopped the progesterone.