Dear Catherine I started using natural progesterone cream and, out of the blue, I had kind of a anxiety/panic attack. When my period started 2 days later I could understand it a little because at that time of the month I always feel very insecure, frightened, scared for the future. Everything in me says it’s something physical because the panic really comes out of the blue and it does not make a difference what the circumstances are. Do you think this has anything to do with my body’s reaction to the progesterone cream? Thank you for reading my email Mary Dear Mary I believe what you are experiencing is a.