Bioidentical Hormones and Stroke Risk

Postmenopausal hormone therapy and risk of idiopathic venous thromboembolism: results from the E3N cohort study

OBJECTIVE: Oral estrogen therapy increases venous thromboembolism risk among postmenopausal women. Although recent data showed transdermal estrogens may be safe with respect to thrombotic risk, the impact of the route of estrogen administration and concomitant progestogens is not fully established.

CONCLUSIONS: This large study found that route of estrogen administration and concomitant progestogens type are 2 important determinants of thrombotic risk among postmenopausal women using hormone therapy. Transdermal estrogens alone or combined with progesterone might be safe with respect to thrombotic risk.

Source: http://www.ncbi.nlm.nih.gov/pubmed/19834106?dopt=Abstract