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1. – Progesterone receptor A-regulated gene expression in mammary organoid cultures. Santos SJ, Aupperlee MD, Xie J, Durairaj S, Miksicek R, Conrad SE, Leipprandt JR, Tan YS, Schwartz RC, Haslam SZ. J Steroid Biochem Mol Biol. 2009;115(3-5):161-72. This experimental study used breast cells from mice, cultured in vitro. First, the behavior of the cells was compared after exposure to either progesterone or the synthetic progestin, promogestone. After seeing similar proliferation with both progestogens, they then went on to conduct gene expression studies (again in the mouse mammary cells) using only the promogestone. They found that certain genes were activated by the promogestone, and these were regulated by progesterone receptor A,.
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