Progesterone Plays a Major Role in Breast Cancer Prevention & Treatment

Drug companies greatly influence how physicians practice

Last month, Dr. Peter Gotzsche, a co-founder of the Cochrane Collaboration – the world’s foremost body in assessing medical evidence – arrived in Australia to speak to Australians about their use of prescription medications.

Dr Gotzsche estimates that 100,000 people die in the U.S. every year from the side-effects of correctly used drugs. That’s right- correctly used drugs. It’s truly refreshing, therefore, to see a doctor speak out against big pharma and instead choose what’s best for his patients.

Research conducted by drug companies provides the basis for much of what is taught in medical schools, and many doctors are not comfortable making medical choices unless a drug company gives them direction.

Patients would be shocked to see how little time we spend in medical school on the female endocrine system. I remember about a week in second year, six weeks in the third year. That was for the entire subject of obstetrics and gynecology. Needless to say, 99% of docs enter the “real world” totally unprepared to answer questions, or provide guidance to our patients. For many docs, their chief source of information is the pharmaceutical industry. This is really a conflict of interest. — Dr Robert W. Patterson, Sanford, NC, USA

Drug companies have never encouraged the use of natural hormones because they cannot patent natural products. Most endocrinologists who specialize in hormones are familiar with the synthetic hormone compounds produced by drug companies; few of them utilize natural hormones because no drug companies recommend them (the exception being when a drug company can patent the delivery system of bioidentical hormones).

Peer reviewed articles like the three linked below provide much needed evidence that topical bioidentical progesterone benefits women in reducing E2-induced proliferations of normal breast epithelial cells in vivo.

It’s time doctors stopped sitting on their hands waiting for big pharma to feed them prescribing information on bioidentical progesterone – one of the most important hormones in the body. We need our doctors to get up to speed … and fast.

Why do I say that? Because the number of breast cancer cases in the U.S. will be 50 percent higher in 2030 than it was in 2011, with an estimated 441,000 cases in 15 years, according to new research by the National Cancer Institute (NCI). The research, presented in April 2015 at the American Association for Cancer Research annual meeting, shows a marked increase in estrogen receptor (ER)-positive tumors in women older than 70.

Women MUST take the reins … and do it NOW … if they are going to give themselves, their daughters, their mothers, and their menfolk any hope of improving their chances of a healthy ageing in the face of such dire predictions.


Balancing our body’s circulating estrogen with progesterone is the key

This universal hormone that provides benefits to both females and males of all ages has been available for over 70 years and yet its true benefits are virtually unknown to the medical community. Peer reviewed articles dating back to 1995 through to 2015 validate topical progesterone (cream/gel) supplementation as an effective form of treatment for many of the health challenges associated with hormone imbalance, chief among them being breast cancer.

While not a cure for cancer, progesterone can dramatically decreases cell multiplication rates, providing women with a degree of protection against estrogen-driven cancers. Levels of progesterone in the body 200 times that of circulating estradiol can, therefore, actually help protect women and men against some forms of cancer initiated and driven by estrogen.

Back in the late 1990s, British gynecologist Dr Katharina Dalton shared with me during a rare phone conversation that “the body sees as natural that which has the same molecular configuration”. She was referring to bioidentical progesterone. Whether made by the body or in a laboratory, biodentical progesterone was considered “safe” because the body recognizes it. A pioneer of premenstrual stress syndrome (PMS) in the 1950s, Dr Dalton believed PMS was brought on primarily by deficiencies of progesterone and could be alleviated by supplementing bioidentical progesterone.

I think we’ve got to appreciate that progesterone receptors are present in men and women equally at all ages, from the fetal stage until death at 100. Dr. Katharina Dalton


Things you can do NOW to protect yourself

  • Be mindful of symptoms that suggest estrogen dominance, and take steps to restore balance.
  • Take the hormone imbalance quiz.
  • If you suspect estrogen dominance, you might consider supplementing with a premium progesterone cream.
  • If you can afford a home test kit, do order one online so you get a baseline of your hormones. Reports are written in easy-to-interpret language.
  • Print out the peer review articles below to share with your GP. Seek his/her support of your decision. If you don’t get it, vote with your feet. Find a practitioner who genuinely wants to learn through your experience using progesterone.
  • Download my FREE ebook 10 Critical Things You MUST Know BEFORE Rebalancing Your Health with Natural (Bioidentical) Progesterone to get up to speed fast on the subject of bioidentical hormones. All you need to get started is distilled in this handy consumer e-guide.
  • Delve into our articles library on Breast Health & Cancer dating back to 2003.
  • Share this article with loved ones in your life whom you believe need to read it.


3 peer reviewed articles validating the use of topical bioidentical progesterone in the prevention and treatment of breast cancer

Influenses of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo (1995)

  • Intervention: Topical application to the breast of a gel containing either a placebo, E2, P, or a combination of E2 and P, daily during the 10-13 days preceding breast surgery.
  • Results: Increased estradiol (E2) concentrations increases the number of cycling epithelial cells. Increased progesterone concentrations significantly decreases the number of cycling epithelial cells.
  • Conclusion: Exposure to progesterone for 10-13 days reduces E2-induced proliferations of normal breast epithelial cells in vivo.

Estradiol and progesterone regulate the proliferation of human breast epithelial cells (1998)

  • Intervention: Daily topical application to both breasts of a gel containing a placebo, estradiol, progesterone, or a combination of estradiol and progesterone during the 14 days preceding esthetic breast surgery or excision of a benign lesion.
  • Result: Increasing the estradiol concentration enhanced the number of cycling epithelial cells, whereas increasing the progesterone concentration significantly limited the number of cycling epithelial cells.
  • Conclusion: Exposure to progesterone for 14 days reduced the estradiol-induced proliferation of normal breast epithelial cells in vivo.

Progesterone receptor modulates estrogen receptor-á action in breast cancer (2015)

  • Summary: Progesterone receptor (PR) expression is employed as a biomarker of estrogen receptor-á (ERá) function and breast cancer prognosis. We now show that PR is not merely an ERá-induced gene target, but is also an ERá-associated protein that modulates its behaviour. In the presence of agonist ligands, PR associates with ERá to direct ERá chromatin binding events within breast cancer cells, resulting in a unique gene expression programme that is associated with good clinical outcome.

Click HERE to access additional research papers on bioidentical progesterone


More evidence …

Image of a breast cancer patient BEFORE application of topical progesterone

Breast Cancer before progesterone cream treatment


Image of same breast cancer patient AFTER 12 months daily application of 20mg topical progesterone cream

Breast Cancer after 1 year progesterone cream treatment


Breast cancer and progesterone receptors (an audio article)

Progesterone has an anti-proliferative effect on breast cancer cells via the progesterone receptor. Research supports the use of progesterone in the treatment of breast cancer.

Progesterone has an anti-proliferative effect on breast cancer cells via the progesterone receptor


Podcast with Dr George Yu

The following podcast (excerpt) with Dr George Yu was recorded by Catherine Rollins in Melbourne, Australia on October 19, 2015.

Podcase with Dr George Yu recorded by Catherine Rollins

Thank YOU for being a part of this amazing community … together we’re changing the health of this world!

As always, if you have any questions, I’m here to extend my support and guidance.

Catherine P Rollins, Founder & CEO
In love & appreciation,
Catherine P. Rollins
Founder & CEO

Ethically Supporting Women’s Choice of BHRT Since 2001