Novel Perspectives for Progesterone in Hormone Replacement Therapy, with Special Reference to the Nervous System
Endocrine Review, Jun 2007; 28: 387 - 439.
In this review, Michael Schumacher et.al. presents a sound case for re-thinking the clinical effects of progestagens beyond the traditional practice of progestin use for endometrial protection only.
This paper highlights the controversial reputation of progestagens as a single class by clarifying the very distinct differences between natural progesterone and progestins.
Summary of large postmenopausal HRT study trials, along with a comprehensive look at progesterone metabolism pathways compels new regard for progesterone as a therapeutic agent.
Salient points regarding the neuroprotective and promyelinating effects of progesterone will pique much interest for the possibility of preventing and/or reversing age-dependent changes and dysfunctions. Schumacher et.al. provide an intriguing platform for the re-evaluation of hormonal aging overall.
