Paget’s Disease of the Breast
Paget’s disease of the nipple is a form of breast cancer, that, in about one-half of patients there will be a mass deeper within the breast.
There is a red, oozing, crusting or scaling nipple lesion (often mistaken for eczema) that does not respond to conservative therapy (topical steroid and antibiotics) should be biopsied.
. In DCIS, the cancer</a> cells are completely contained within the milk ducts.</p>
<p>Around half of the women who have Paget’s disease will have a breast lump that can be felt at the time it is diagnosed.</p>
<p>The alert physician may biopsy the nipple revealing the characteristic changes. Under the microscope, there is a proliferation of malignant epithelial cells scattered throughout the epidermis. </p>
<p>Most commonly, this is an infiltrating ductal carcinoma but occasionally a ductal carcinoma in situ (DCIS) may be present. Overall, this cancer</a> is rare, comprising 1-2% of all patients with breast carcinoma.</p>
<p>Paget’s disease begins on the nipple or areola and is associated with bleeding, itching, and scaling. This is something that would not resolve spontaneously (like sores). </p>
<p>The cause of Paget’s disease is unknown, but certain women seem to be at a higher risk of developing breast cancer</a>. This includes women who have never had children, or had them late in life, women who started their periods at a young age or who had a late menopause</a></a>, and women who have a strong family history of breast cancer</a>.</p>
<p>The first symptom is usually an eczema-like rash, as described earlier. The skin of the nipple and areola may be red and inflamed. There may also be crusting, bleeding and ulceration. Some women have an itching or burning sensation. Fluid (discharge) may leak from the abnormal area of cells. The nipple may turn inwards (be inverted). There may or may not be a lump in the breast.</p>
<p>The treatment of Paget’s disease of the breast will depend on: </p>
<ul>
<li>whether or not there is an underlying breast cancer</a></li>
<li>whether it is DCIS or an invasive tumour </li>
<li>how much of the breast is affected.</li>
</ul>
<p>Hormonal therapies are commonly used for treating breast cancer</a>. They reduce the production of hormones within the body, or prevent the hormones from stimulating the <a href=http://NPAN2006.cancer</a>1.hop.clickbank.net target=top>cancer</a></a> cells to grow. Hormonal therapy is mainly used if the cancer</a> is invasive, but may also be given to women who have DCIS. Tamoxifen and anastrozole (Arimidex®) are two commonly used hormonal treatments. </p>
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